Can We Repair The Ageing Brain? – A Question of Science with Brian Cox

The Francis Crick Institute November 12, 2025
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The Francis Crick Institute

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Our mission is discovery without boundaries. We're an independent charity and biomedical discovery institute, home to more than 1,500 scientists working to understand health, disease and how life works. We explore biological mechanisms at all scales from molecules through cells to organisms. To deliver our mission, we bring together expertise from different scientific disciplines and work with different types of organisations across the academic, clinical and industrial spheres. Our discoveries enhance our understanding of the fundamental processes of life, and have the potential to transform the prevention, diagnosis and treatment of human disease. By opening our doors to the public and taking our science out into the world, we make lasting connections for maximum impact. Welcome to the Crick – where discoveries change lives and ideas find room to grow. Banner image credit: Katy Hole (Postdoc), Mitochondrial Neurobiology Lab, 2023.

Video Description

Professor Brian Cox and our expert panel explore the science of Alzheimer’s, Parkinson’s and other conditions that cause dementia. More than 55 million people around the world are living with dementia, with the number set to rise in ageing populations. How close are we to effective, affordable treatments? What are the genetic risks? Can we prevent it developing? The panel takes a deep dive into dementia research and where it’s headed, from early detection to the latest drug trials and whether diet, exercise or even doing puzzles like Sudoku really make a difference. #dementia #parkinsonsdisease #alzeheimersdisease *In this episode* 0:00 What’s this episode about? 0:24 What is dementia? 7:16 Is it ever too late to delay dementia? 9:48 Is it different in people with higher intellectual ability? 13:39 Is the immune system involved? 18:00 What role do genetics play? 20:26 Can physical exercise, diet or brain games help? 24:18 Why do clinical trials take so long? 27:40 Do digital devices contribute? 30:23 What medicines are in development? 36:51 Which treatments show the most promise? 42:20 Will there be a cure? *Panellists* • Bart de Strooper – Professor and Group Leader, Cellular Phase of Alzheimer’s Disease Laboratory, Francis Crick Institute and UK Dementia Research Institute • Julie Williams – Professor and Group Leader, Cardiff University and UK Dementia Research Institute • Rory Cellan-Jones – Health and technology writer and presenter of Movers and Shakers • Sonia Gandhi – Professor of Neurology, UCL, Assistant Research Director, Francis Crick Institute and Honorary Consultant Neurologist, National Hospital for Neurology and Neurosurgery *A Question of Science* A Question of Science is a groundbreaking series of panel discussions where experts from different fields respond to your questions, sharing the scientific perspective on society’s most pressing questions. A Question of Science is BBC Studios production for the Francis Crick Institute. *The Francis Crick Institute* The Francis Crick Institute is one of the biggest research institutes in Europe. We’re an independent lab and registered charity, and home to more than 1,500 scientists working to understand health, disease and how life works.

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