Endocrinology | Receptor Pathways

Video Description

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this endocrine physiology lecture, Professor Zach Murphy walks you through the essential Receptor Pathways that mediate hormone signaling in the human body. This foundational session highlights the key differences between peptide and steroid hormones, focusing on how they interact with either membrane-bound or intracellular receptors to produce their physiologic effects. We begin by reviewing lipid-soluble steroid hormones, which enter cells to bind nuclear receptors and influence gene transcription, followed by a deep dive into water-soluble peptide hormones that act through second messenger systems. The lecture emphasizes G protein-coupled receptors (GPCRs), their associated Gs, Gi, and Gq pathways, and how these cascades regulate intracellular messengers like cAMP, IP₃, DAG, and calcium. Clinical relevance is woven throughout, helping you connect these signaling pathways to pharmacologic targets and endocrine diseases. Additionally, we clarify a common point of confusion regarding enzyme classification: Minor correction 27:05 — Phosphodiesterase does not break down phospholipase C. Instead, phospholipase C is itself a type of phosphodiesterase, catalyzing the cleavage of PIP₂ into IP₃ and DAG. Enjoy the lecture and support us below! Table of Contents: 00:00 Lab 00:20 Types of hormones 00:47 Peptide hormones 02:32 Second Messenger Systems 03:10 Steroid hormones 05:15 G Stimulatory pathway 14:00 GQ pathway 21:20 Oxytocin & muscle contraction 22:28 Steroid Hormones Pathway 25:44 G Inhibitory Pathway & PDE 27:35 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media https://www.tiktok.com/@ninjanerdlectures https://www.instagram.com/ninjanerdlectures https://www.facebook.com/ninjanerdlectures https://x.com/ninjanerdsci/ https://www.linkedin.com/company/ninja-nerd/ 💬 Join Our Community Discord: https://discord.gg/3srTG4dngW #ninjanerd #ReceptorPathways #Endocrinology