High Cholesterol and Plaque Regression?! Updates on KETO-CTA with Dave Feldman

Nick Norwitz September 5, 2025
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Nick Norwitz

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MD, Harvard & PhD, Oxford & | My Motto is "Stay Curious" | Enthusiastic About All Matters Metabolic Health | Thanks for Learning with Me! Please also follow at my Newsletter at "StayCuriousMetabolism.com" where you can find more deep dives into metabolism that will be worth your time and upgrade your health. Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.

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In this conversation with Dave Feldman, we explore updates on the controversial KETO-CTA study, and what it reveals about LDL cholesterol, ApoB, plaque progression, and heart disease risk, especially in lean mass hyper-responders on a ketogenic diet. We also discuss the debate and controversy surrounding the study, why we’ve had to remain quiet for so long, and the new results that have resulted from this study in the past few months. Whether you’ve been following the debate and drama, or if you’re interested in cholesterol science, ketogenic diets, cardiovascular imaging, or the debate over LDL and heart disease, this interview is a fun and educational watch. Dave’s Presentation on Heart Flow vs Cleerly vs QAngio: https://youtu.be/aJobOSRdIOM?si=ZOlkqtMvpXwLn9nO Nick’s LDL 574 mg/dl article and video, Coming Soon at https://StayCuriousMetabolism.com Chapters 00:00 – Setting the stage for the big questions on LDL and plaque 01:22 – Inside the KETO-CTA study and why it matters 06:08 – Baseline results and comparison with the Miami Heart study 09:02 – Main findings: plaque predicts plaque, not LDL or ApoB 11:19 – The controversy behind the April 7th paper 15:40 – Managing internal doubts and publication decisions 22:56 – The Cleerly quality control debate explained 30:35 – The HeartFlow and QAngio data 35:46 – Evidence of plaque regression in the KETO-CTA study 38:28 – Explaining plaque regression with data and scans 46:22 – Key takeaways and final thoughts #keto #ketodiet #ketolifestyle #lowcarb #lowcarbdiet #ketogenicdiet #metabolichealth #cholesterol #ldl #apob #lipids #lipidscience #lipidology #heartdisease #cardiovascularhealth #cardiovascularrisk #hearthealth #plaqueprogression #plaqueregression #coronarycalcium #heartscans #coronaryimaging #ketoctastudy #davefeldman #nicknorwitz #cholesterolscience #cholesterolmyths #nutritiondebate #dietscience #nutritionresearch #medicalresearch #healthresearch #metabolicresearch #ketoscience #dietdebate #metabolichealthresearch #preventivemedicine #healthoptimization #scienceandhealth #controversialscience #staycurious

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