Is Your Parkinson’s Medication Wearing Off Too Soon? Here’s What to Do
Dr. Luis E Zayas, MD PT
@luisezayasmdpt4397About
This channel offers educational content on Parkinson’s disease and other related topics. It is hosted by Dr. Luis Zayas, a U.S. board-certified physician in Neurology, Internal Medicine, and Epilepsy, who began his career as a physical therapist in NJ and PR. He completed residency training in Internal Medicine at St. Barnabas Hospital, Neurology residency at Cooper University Hospital, and fellowship training in Neurocritical Care at the Cleveland Clinic and Movement Disorders at the University of Nebraska. Disclaimer The content is intended for educational purposes only. It is not medical advice, does not establish a physician-patient relationship, and should not be used to diagnose or treat any medical condition. Always seek the guidance of a qualified provider with any questions regarding a medical condition. Use of this channel, including comments or messages, does not create a professional relationship and is not a substitute for in-person care with a licensed provider.
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What Are Motor Fluctuations in Parkinson’s Disease? Understanding ON and OFF Times When we talk about motor fluctuations in Parkinson’s disease, we’re mainly referring to something called “wearing OFF.” This means your Parkinson’s medication, such as levodopa, stops working before your next scheduled dose. As a result, your symptoms return—usually 1 to 2 hours before your next pill. Here’s what you need to know: ✅ ON Time What it means: Your Parkinson’s medication is working. When it happens: Usually 30 to 45 minutes after taking your dose. What you’ll feel: Improved movements, less stiffness, and sometimes reduced tremor. ❌ OFF Time What it means: The effect of the medication has worn off. What you’ll feel: Stiffness, slowness, or tremor returns. Why it happens: There’s less dopamine in your brain because the medication is no longer active. 👉 In order to feel OFF, you first need to feel ON. Recognizing these changes can help you and your doctor adjust your treatment for better symptom control. 📺 Related Videos: Side effects of dopamine agonists (ropinirole, pramipexole, rotigotine patch, apomorphine) 👉 https://www.youtube.com/watch?v=9V0XvDtsLMw How to treat dyskinesias in Parkinson’s disease 👉 https://www.youtube.com/watch?v=z_w6OZasyuo&t=267s I hope you enjoy this video and find it helpful. For more information, visit our website: 🌐 https://www.gemneurology.com — Dr. Z Luis E. Zayas, MD, PT GEM Neurology PLLC, Clinton, TN Board-certified in Internal Medicine and Neurology by the American Board of Internal Medicine and the American Board of Psychiatry and Neurology. Fellowship-trained in Movement Disorders and Neurocritical Care. Former licensed physical therapist in New Jersey and Puerto Rico.
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