Most Longevity Experts Don't Tell You This About Aging | 56 - Longevity Science #8

Video Description

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Biological Age & what it REALLY means: https://youtu.be/DcxgEwQKx8Q The Surprising Way Body Size Relates to Lifespan: https://youtu.be/Fjh6WbkZkvw The Benefits of Protein Restriction, How Protein Affects Hormones & FGF21: https://youtu.be/Nf1GhkAFiWY An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ Depending on how you look at them, aging genes are genes whose expression changes in a predictable with age or genes that influence an organism's lifespan by affecting various biological processes associated with aging. Research on aging genes not only deepens our understanding of the biological aging process, but also opens up potential avenues for developing therapies aimed at extending healthy human lifespan. By targeting these genes, scientists hope to delay the onset of age-related diseases such as Alzheimer's disease, cardiovascular disease, and cancer, ultimately promoting a longer and healthier life. In this episode, Matt discusses several ways we can identify and categorize aging genes. He talks about how genes can serve as predictive signatures of chronological or biological age, potential conserved genetic regulators of longevity, and how unbiased genetic screens can still be biased. He also provides his unique perspective on aging genes in humans and the potential to optimize longevity through genetic modulation. 0:00 Introduction 1:05 Definition 1 of an aging gene 2:23 Definition 2 of an aging gene 2:58 Genes as biomarkers of aging, biological age clocks 7:07 Nuances of definition 2 9:25 What we should be focusing on 10:59 The daf-2 gene and lifespan 12:41 The sir2 gene and lifespan 13:31 FGF21 and lifespan 14:28 Growth hormone mutants and lifespan 15:42 FOXO3a and longevity in humans 17:10 APOE genes and longevity in humans 18:06 Things to keep in mind when talking about aging genes 22:35 Matt blows your mind 31:03 Wrapping up Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!