NEW 2025 Meta-Analysis: RCTs Don’t Support Restricting Saturated Fat

Nick Norwitz July 11, 2025
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Nick Norwitz

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MD, Harvard & PhD, Oxford & | My Motto is "Stay Curious" | Enthusiastic About All Matters Metabolic Health | Thanks for Learning with Me! Please also follow at my Newsletter at "StayCuriousMetabolism.com" where you can find more deep dives into metabolism that will be worth your time and upgrade your health. Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.

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For decades, we've been told that saturated fat is harmful to heart health. But is it finally time to stop blaming butter and other sources of saturated fat for heart disease? In this video, we dive into a new 2025 meta-analysis of randomized controlled trials (RCTs) that reveals “the evidence available from RCTs does not support saturated fat restriction for the prevention of cardiovascular disease.” The study challenges long-standing beliefs about dietary fat and its role in heart health, sparking a crucial conversation about how we approach heart disease prevention and cholesterol management. We’ll explore the implications of this new evidence, discuss why there's still confusion around this issue, and offer practical insights on healthy fats, dietary guidelines, and cardiovascular health. Stay tuned for key takeaways from this meta-analysis and learn why saturated fat might not be the culprit we've been led to believe. REFERENCES AND MORE INFORMATION A written breakdown of these data will all references hyperlinked can be found in the June 16, 2025, letter at: http://StayCuriousMetabolism.com . The letter includes descriptions on how to understand forest plots, my conflicts of interest, which are certainly not aligned with “Big Butter” – quite the opposite, actually. CARDIOCHEK METER To get your own CardioChek from Blood Chek Medical, follow this link. Use Discount Code “DrNicholasNorwitz” for $50 off CardioChek Plus Analyzer: https://bloodchekmedical.com/pages/cardiochek-dr-nicholas-norwitz/aff=2 REFERENCED VIDEOS $170 Million Mistake: https://youtu.be/6xm1gzPSTR0 C15: https://youtu.be/fKt3S25Q-as Ketogenic Diet, Stearic Acid, and Colon Cancer: https://youtu.be/GGbQDstmty4 Stearic Acid & Mitochondrial Health: https://staycuriousmetabolism.substack.com/p/this-saturated-fat-can-burn-fat-a?r=40ekz2 Sat Fat N = 1: https://youtu.be/j0ClcgNBeec Chapters 0:00 – A New 2025 Meta-Analysis of Randomized Controlled Trials: Is It the Saturated Fat? 0:49 – Why There’s Still Confusion Around Saturated Fat and Heart Disease 1:13 – The Meta of RCTs Says: No Benefits to Reducing Saturated Fat Intake 2:50 – No Dose-Response: Less Butter Isn’t Better 3:43 – Summary: “The existing Human RCT data do not support…” 4:00 – Discrepancies Among Meta-Analyses: What Should We Trust? 5:25 – Why the Status Quo Persists in Saturated Fat Guidelines 6:32 – Financial Influences in Dietary Recommendations 7:13 – Saturated Fat: Oversimplified and Misunderstood 10:38 – Individual Differences: Why We Respond Differently to Saturated Fat 11:53 – How to Measure Cholesterol Levels at Home 12:18 – Revising the Evidence: Let’s Focus on Data, Not Dogma #saturatedfat #dietdogma #RCT #randomizedcontrolledtrials #metaanalysis #ketodiet #ketosis #carnivorediet #butter #educaitonal #informative #cholesterol #LDL #HDL #ApoB #hearthealth #veganmeat #plantbased #metabolism #metabolichealth #MCT #SCFA #C15 #stearicacid #essentialnutrient #mitochondrialhealth #microbiome #insulin #insulinresistance #sugarfree #heartdiseaseprevention #saturatedfatdebate, #cholesterolmyths, #metaanalysis2025 #fatandhearthealth #saturatedfatfacts, #hearthealthresearch #dietaryguidelines #nutritionscience #dietandheartdisease #scientificstudy #cholesterollevels #cardiovascularresearch #cholesteroldebate #healthytips #staycurious

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