The future of remote work, juggling APIs, and dream integrations with Wade Foster of Zapier | E2221

This Week in Startups December 10, 2025
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This Week in Startups

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Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators. If you want to ask a question about your career, your startup or angel investing email [email protected]. Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Jason: https://linktr.ee/calacanis Follow This Week in Startups on Twitter: https://twitter.com/TWiStartups Subscribe to TWiST Clips for the BEST moments: https://www.youtube.com/channel/UCS7tJlcUA6PzVHEMo-X7ddg?sub_confirmation=1

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This Week In Startups is made possible by: Goldbelly - http://Goldbelly.com Every.io - http://every.io/ Zite - http://zite.com/twist Today’s show: Today, Zapier’s a multi-billion company helping enterprises integrate AI agents and other time-saving shortcuts into their workflows… but we had the founder on TWiST when they were just getting started! In a 2016 chat, founder Wade Foster walked JCal through their 2012 seed round, running a small entirely remote team with no HQ, the complexities of building a tool that relies on third-party APIs, and why Microsoft Office was the “Holy Grail” for his integration software. PLUS we’ve got a new entrant in your Gamma Pitch Deck competition! Tour CEO/CTO Amulya Parmer tells us how his app is saving property managers time and grief, while eliminating “looky-loos” and increasing their “hit rate.” FINALLY, Alex chats with Tomas Puig of TWiST 500 marketing analysis startup Alembic. It turns out, LLMs aren’t ideal for scrutinizing marketing campaigns because they lack the requisite historical data. Find out how they’re using Spiking Neural Networks (SNN) to dig deeper than GPT and Claude can go. Timestamps: (02:40) Amulya from Tour opens the show with praise for Jason (03:34) Tour’s 2-minute Gamma pitch: automated property tours for managers (06:47) Why Jason thinks Tour is an ideal tool for Gen Z (10:01) Goldbelly - Goldbelly ships America’s most delicious, iconic foods nationwide! Get 20% off your first order by going to http://Goldbelly.com and using the promo code TWiST at checkout. (13:32) How Tour can eliminate “looky-loos” and increase the “hit rate” (14:38) Why Tour prices based on individual properties and apartments (19:14) Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit http://every.io. (20:23) Jason wants to sprinkle some AI into Tour (24:29) Welcoming Tomas Puig from Alembic (25:12) Does epic-scale brand marketing actually pay off for these brands? (27:27) The hardest thing about being a marketer… (28:31) Alembic’s origins: organizing huge unstructured data sets (30:22) Zite - Zite is the fastest way to build business software with AI. Go to http://zite.com/twist to get started. (31:27) Case Study: making sense of Delta’s Olympics data (33:37) Applying simulation models and supercomputers to marketing data (35:48) How Spiking Neural Networks (SNN) help Alembic spot trends and link causal relationships (41:13) The key advantage of training models on private data (43:16) Building their own clusters vs. renting (44:41) “You don’t ask if you have Product Market Fit… You hold on for dear life.” (46:28) Flashback with Alex and Lon to Jason’s 2016 chat with Wade Foster of Zapier (54:48) The dangers of building atop other platform’s APIs (01:03:00) What Zapier learned pre-pandemic about leading remote teams (01:13:12) Why MS Office was the “Holy Grail” for early Zapier Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com Check out the TWIST500: https://www.twist500.com Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp Follow Lon: X: https://x.com/lons Follow Alex: X: https://x.com/alex LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm Follow Jason: X: https://twitter.com/Jason LinkedIn: https://www.linkedin.com/in/jasoncalacanis Thank you to our partners: (10:01) Goldbelly - Goldbelly ships America’s most delicious, iconic foods nationwide! Get 20% off your first order by going to http://Goldbelly.com and using the promo code TWiST at checkout. (19:14) Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit http://every.io. (30:22) Zite - Zite is the fastest way to build business software with AI. Go to http://zite.com/twist to get started. Great TWIST interviews: Will Guidara https://youtu.be/pvJa2pzuXWQ Eoghan McCabe https://youtu.be/9dHN4YFkgv4 Steve Huffman https://podcasts.apple.com/us/podcast/reddit-ceo-steve-huffman-on-mod-revolt-building-a/id315114957?i=1000617333424 Brian Chesky https://podcasts.apple.com/ca/podcast/airbnb-ceo-brian-chesky-on-early-rejection-customer/id315114957?i=1000611761112 Bob Moesta https://youtu.be/y2UMzSqX94Q Aaron Levie https://podcasts.apple.com/ca/podcast/box-ceo-aaron-levie-breaks-down-box-ai-and-generative/id315114957?i=1000612384545 Sophia Amoruso https://podcasts.apple.com/ca/podcast/sophia-amoruso-on-branding-raising-a-fund-portfolio/id315114957?i=1000601352978 Reid Hoffman https://podcasts.apple.com/ca/podcast/reid-hoffman-on-ais-crescendo-moment-regulation-and/id315114957?i=1000612548498 Frank Slootman https://podcasts.apple.com/ca/podcast/snowflake-ceo-frank-slootman-on-moving-the-needle-win/id315114957?i=1000602560622 Billy McFarland https://podcasts.apple.com/ca/podcast/billy-mcfarland-on-fyre-fest-fraud-failure-hacking/id315114957?i=1000610922577

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