The Power of CAC = 0: When Does LDL Matter?

Nick Norwitz June 2, 2025
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Nick Norwitz

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MD, Harvard & PhD, Oxford & | My Motto is "Stay Curious" | Enthusiastic About All Matters Metabolic Health | Thanks for Learning with Me! Please also follow at my Newsletter at "StayCuriousMetabolism.com" where you can find more deep dives into metabolism that will be worth your time and upgrade your health. Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.

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Medical management of heart disease is evolving rapidly with the advancement of cardiac imaging technology. These innovations provide better insights into personalized medicine, allowing us to understand cholesterol levels in a new light. The outdated idea that high cholesterol is always dangerous is being challenged by emerging research. In this video, we dive into data that shows high LDL cholesterol isn’t always a useful risk factor for heart disease. This isn’t an excuse to disregard your doctor’s advice, but we aim to arm you with the facts, scientific evidence, and logic to help you make informed decisions. In this video, we will also give you the data to back up your next conversation with your healthcare provider. If you’re interested in taking a proactive approach to your cardiovascular health, let’s dive in. Remember, this is not medical advice—but empowered decision-making can change your health trajectory. Let’s get started! For a written breakdown and all references, see the associated StayCurious Metabolism Newsletter: https://staycuriousmetabolism.substack.com/p/the-power-of-cac-0-does-ldl-cholesterol?r=40ekz2 Chapters: 0:00 – Medical Management of Heart Disease Is Evolving 0:22 – LDL and ApoB: Why the Old Cholesterol Dogma is Fading 1:02 – 23,132 Person Study: Does LDL Matter When CAC = 0? 4:20 – Long-Term Data: 16.6 Year Study Confirms the Findings 5:18 – Metabolic Health's Role: HDL Cholesterol, Diabetes, and Heart Disease 5:58 – A Case For Caution: A Metabolic Syndrome King Kong 7:34 – Age and Heart Disease: Why CAC Isn’t Always a Predictor for Younger People 8:40 – Radical Transparency: How I Think Through my Personal Case 9:57 – The Future of Heart Disease Care: How Technology Will Change Treatment 10:38 – Moving Beyond Cholesterol Dogma: A New Approach to Heart Health 11:43 – American College of Cardiology: CAC Scores and Statin Use Explained #hearthealth #CAC #metabolichealth #cholesterol #LDL #ApoB #personalizedmedicine #cardiovascularhealth #cardiovasculardisease #HDL #Diabetes #BloodPressure #heartdisease #PowerofZero #atherosclerosis #metabolism #educational #informative #CCTA #staycurious #cardiacimaging #wellnessjourney #cholesterolmyths #metabolicsyndrome #cardiologist #CACscore #statins #healthtech #advanceddiagnostics #heartdiseaserisk #LDLcholesterol #cardiovascularcare #cardiovascularscreening #personalizedhealthcare #heartdiseaseprevention #hearthealthtips #cardiacwellness #cholesterolmanagement #cardiacresearch #vascularhealth #cholesterolfacts #healthtechnology #sciencebacked #cholesteroldebate #bloodlipids #heartmonitoring

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