The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7

Video Description

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep. #DavidSinclair #Longevity #BrainHealth Thank you to our sponsors: Athletic Greens - https://athleticgreens.com/sinclair InsideTracker - https://insidetracker.com/sinclair Levels - https://levels.link/sinclair Our Patreon page: https://www.patreon.com/davidsinclair Lifespan book: https://amzn.to/3sUqurT Lifespan podcast website: https://www.lifespanpodcast.com Dr. David Sinclair Social: Instagram - https://www.instagram.com/davidsinclairphd Twitter - https://twitter.com/davidasinclair Facebook - https://www.facebook.com/davidsinclairphd Stay up to date with David's work to democratize biological age testing and insights: https://www.tallyhealth.com Matthew LaPlante's Social: Twitter - https://twitter.com/mdlaplante Timestamps: 00:00:00 Introducing Episode Seven: Aging of the Brain 00:04:39 Thanking the Sponsors 00:07:38 Ex-differentiation as a Driver of Aging 00:09:22 The Brain Ages Slowly 00:14:17 Cognitive Function and Plasticity 00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins 00:23:26 Plant-based Diets and B-vitamins 00:28:32 Homocysteine, Plaque, and Vasculature 00:32:35 Fatty Acids 00:35:48 Physical Activity 00:39:14 Metformin 00:46:02 NAD Boosters 00:50:33 Increasing Blood Flow 00:53:20 Sleep 00:58:02 Overall Message: Keep your Brain Healthy 00:58:50 Next Week’s Episode and the Future of Medicine 01:01:21 Options for Subscription for Support Links: The cerebellum in the brain ages slowly: https://bit.ly/3JC9CLL Neuronal cells have a lower epigenetic age: https://bit.ly/3HVZsVA Sirt1 regulates aging in mice: https://bit.ly/3sGZPNC Mediterranean diet and brain health: https://bit.ly/3uUpYuL Mediterranean diet and dementia risk: https://bit.ly/34Igp7H Aerobic exercise improves executive functioning: https://bit.ly/34Dv5oJ Exercise and mouse models of neurodegenerative disease: https://bit.ly/3516IRn Strength exercises elevate the expression of BDNF: https://bit.ly/3GTLqCs Metformin enhances cognitive ability in fish: https://bit.ly/3sLtWn2 Alzheimer’s disease and metformin: https://bit.ly/3GSdTJ5 Metformin use correlates with a reduced risk of dementia: https://bit.ly/3GT0KPO NAD boosting and Alzheimer’s disease: https://bit.ly/367C2P2 ALS, nicotinamide riboside, and pterostilbene: https://bit.ly/3Bm2VKN Vascular aging and NAD in mice: https://bit.ly/34Uemgx In mice, overexpressing Sirt1 in the brain extends lifespan: https://bit.ly/3HNRyh3 Sirt1 ameliorates amyotrophic lateral sclerosis in mice: https://bit.ly/3LvUWiO Sirt1 protects against Alzheimer’s disease in mice: https://bit.ly/34KZXUe Sirt1 and neuroprotection in a mouse model of Huntington’s disease: https://bit.ly/3BqymDJ Sleep loss reduces lifespan in flies: https://bit.ly/3Jt6BgA A single night of sleep deprivation increases amyloid-beta: https://bit.ly/3uSNGaU All-cause mortality correlates with sleep duration: https://bit.ly/3rQl14f Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed. Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.