Does Insulin cause Atherosclerosis?

Video Description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]* Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* 1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender 0:00 - Introduction 0:51 - Insulin - Plaque Forming? 2:15 - Dying Quickly or Dying Slowly? You Choose. 5:02 - Any Scientific Merit? 6:27 - Normal Pathway: Akt 7:23 - Cell Migration, Abnormal Pathway: ERK 8:01 - Separating Insulin from Insulin Resistance 12:00 - Unique Cellular Reaction to Insulin Resistance 13:07 - Main Points References [A] Bornfeldt KE, Tabas I. Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 2011;14(5):575-585. doi:10.1016/j.cmet.2011.07.015 [B] Lightell DJ Jr, Moss SC, Woods TC. Loss of canonical insulin signaling accelerates vascular smooth muscle cell proliferation and migration through changes in p27Kip1 regulation. Endocrinology. 2011;152(2):651-658. doi:10.1210/en.2010-0722 [C] Rask-Madsen C, Buonomo E, Li Q, et al. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2012;32(5):1124-1131. doi:10.1161/ATVBAHA.111.239558 [D] Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA. Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia. 1994;37(10):1025-1035. doi:10.1007/BF00400466 ********CRITIQUES, RULES, AND NOTES******** Be aware of the following rules before posting comments: - Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique: Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES: If your comment is rude, you will be banned. If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response. If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritique Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes. #insulinresistance #diabetesawareness