The Most Incredible Fasting Study I’ve Ever Read

Physionic October 27, 2025
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Physionic

@physionic

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Detailed multi-study analyses, clear explanations of mechanisms underlying the results, and a sprinkling of cheeky humor. Learn your body, from the macro to the micro - welcome to Physionic. Credentials: - Ph.D. in Molecular Medicine (Cell Physiology) - Masters in Exercise Physiology - 10 Years Experience in Laboratory Work - Previous American College of Sports Medicine Certification - Non-Degree in Nutrition Science (1.5 years undergraduate education) - Classroom Professor (T.A. in 2015) in Health, Nutrition, and Physiology since 2016 Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

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*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]* Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy *JOIN THE COMMUNITY* Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* 1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender Fasting increases Inflammation: https://youtu.be/Sj-SezJXrqA?si=vZh8fHNJDP-2110e Fasting and Autophagy in Immune Cells: https://youtu.be/PfsIfpt0E3g?si=CsaA0GC-baEP1uL3 0:00 - Introduction 0:28 - Incredible Fasting 8:07 - Main Points/Take Aways Reference [Study 534] Naveen Kumar GV, Wang R-S, Sharma AX, et al. Non-canonical lysosomal lipolysis drives mobilization of adipose tissue energy stores with fasting. Nat Commun. 2025;16:1330. doi:10.1038/s41467-025-56613-3 Funding/Conflicts: Public Funding: This work was supported by the National Institutes of Health: KL2 TR002542 (to P.K.F.); R01 DK137913 (to M.L.S.); no other public grants are listed.; Non-Profit Funding: No non-profit funders are listed; no non-profit grants are disclosed in the acknowledgements.; Industry Funding / Conflicts: The authors report no industry funding for this study; outside the submitted work, P.K.F. reports consulting for Regeneron; advisory board service for Camurus, Crinetics, and Amryt/Chiesi; and research funding from Crinetics, Corcept, and Quest; all other authors declare no competing interests. ********CRITIQUES, RULES, AND NOTES******** Be aware of the following rules before posting comments: - Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique: Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES: If your comment is rude, you will be banned. If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response. If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritique Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes. #fasting #fastingforhealth #fastingscience

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