How one psychedelic trip can alter an entire lifetime | Matthew Johnson: Full Interview

Big Think November 28, 2025
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Big Think exists to make you smarter, faster. Through conversations with the world’s brightest thinkers, we bring you the ideas shaping the future of science, philosophy, culture, and the human mind. Our library of thousands of videos distills complex insight into clear, actionable wisdom for how to think, work, and live in a changing world. Meet legendary teachers like philosopher Daniel Dennett, physicist Brian Cox, classicist Mary Beard, psychiatrist Bessel van der Kolk, political scientist Ian Bremmer, anthropologist Helen Fisher, and hundreds more — all sharing the ideas that define our time and the questions that will shape our future.

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Become a Big Think member to unlock expert classes, premium print issues, exclusive events and more: https://bigthink.com/membership/?utm_source=youtube&utm_medium=social&utm_campaign=yt_desc “Psychedelics crosscut so many interesting domains. They've been used for time immemorial by indigenous cultures. In our own Western cultural history, they really exploded on the scene in the 1960s, and were associated with radical changes to society.” Subscribe to Big Think on YouTube ► https://www.youtube.com/channel/UCvQECJukTDE2i6aCoMnS-Vg?sub_confirmation=1 Up next, Are drugs really frying your brain? | Dr. Carl Hart ► https://www.youtube.com/watch?v=90MHZbXrmY0 Psychedelic research is enjoying a renaissance. Matt Johnson, a professor of psychiatry and behavioral sciences at Johns Hopkins, is at the forefront of the movement to redefine our understanding of the mind and its interaction with these powerful substances. As psychedelic compounds steadily enter the sphere of clinical trials, Johnson's groundbreaking research underscores their potential to bring about a paradigm shift in psychiatry, neuroscience, and pharmacology. 0:00 Meet Dr. Matthew Johnson 0:25 Why are psychedelics unique among drugs? 3:42 What does the term ‘psychedelic’ mean? 7:40 What is hallucinogen vs. entheogen vs. psychedelic? 13:46 The first wave: Hofmann, Leary, and the CIA 18:54 Are psychedelics legal? 21:39 What are the main effects of psychedelics? 24:28 How do psychedelics work in the brain? 39:57 Are psychedelics dangerous? What is the link to schizophrenia? 48:43 What are the biggest risks of psychedelics? 50:42 How do “all arounders” get to the core of psychiatric disorders? 54:48 What is the role of a guide in a psychedelic session? 58:22 What is the focus and impact of your research? 1:03:44 What really amazes you in your research? 1:09:54 Why are we in a psychedelic renaissance? 1:17:09 What are some pitfalls of psychedelic medicine? Read the video transcript ► https://bigthink.com/series/full-interview/psychedelic-drugs-101/?utm_source=youtube&utm_medium=video&utm_campaign=youtube_description © Freethink Media Inc., All Rights Reserved. ---------------------------------------------------------------------------------- Go Deeper with Big Think: ►Become a Big Think Youtube Member Get exclusive classes and early, ad-free access to new releases without leaving Youtube. https://www.youtube.com/@bigthink/membership/ ►Become a Big Think Web Member Get the entire Big Think Class library, premium print issues, live events, and more. https://bigthink.com/membership/ ►Subscribe to Big Think on Substack Get all of your favorite Big Think content delivered to your inbox. https://bigthinkmedia.substack.com/subscribe/ ---------------------------------------------------------------------------------- About Matthew Johnson: Matthew W. Johnson, Ph.D., is The Susan Hill Ward Endowed Professor of Psychedelics and Consciousness Research at Johns Hopkins. Working with psychedelics since 2004, he is one of the world’s most widely published experts on psychedelics. He has published research on psychedelics and mystical experience, personality change, tobacco smoking cessation, cancer distress treatment, and depression treatment. In 2021 he received as principal investigator the first grant in 50 years from the US government for a treatment study with a classic psychedelic, specifically psilocybin in treatment of tobacco addiction. He is also known for his expertise in behavioral economics, addiction, sexual risk behavior, and research with a wide variety of drug classes. He’s been Interviewed by Anderson Cooper on 60 Minutes, the New York Times, the Washington Post, the Wall Street Journal, CNN, NPR, Fox News, Fox Business News, BBC and in Michael Pollan’s book How to Change Your Mind.

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