Microbiote intestinal : agissez sur votre immunité, santé mentale et risque de cancer - Pr Joël Doré

Alan December 3, 2025
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🤔 Et si des milliards de micro-organismes vivant dans vos intestins détenaient la clé de votre santé ? Et si votre microbiote pouvait prédire votre réponse à un traitement contre le cancer ? Pouvons-nous vraiment transformer notre santé en nourrissant ces bactéries que nous portons en nous ? 🎙️ Ces questions ne relèvent plus de la science-fiction. C'est la révolution que nous dévoile le Professeur Joël Doré dans ce nouvel épisode de Healthier Humanity. 👨🏼‍⚕️Pionnier de la recherche sur le microbiote intestinal, le Professeur Doré nous dévoile les secrets de ce qu'il appelle "l'organe oublié" - ces 50 000 milliards de micro-organismes avec lesquels nous vivons en symbiose permanente. Directeur de recherche à l'INRAE et directeur scientifique de Metagenopolis, il a consacré plus de 40 ans à explorer cet écosystème fascinant, à une époque où ce domaine était encore considéré comme exotique. Aujourd'hui, ses travaux révolutionnent notre compréhension des liens entre le microbiote et de nombreuses maladies chroniques, neurodégénératives et neuropsychiatriques. Entrepreneur visionnaire, il a cofondé MaaT Pharma, qui développe des thérapies microbiomiques révolutionnaires pour l'oncologie, et pilote le French Gut, un projet ambitieux visant à cartographier la diversité du microbiome français avec 100 000 échantillons d'ici 2029. 🦠 Dans cet épisode, il décortique les liens fascinants entre notre microbiote et des maladies aussi diverses que les pathologies métaboliques, cardiovasculaires, neurodégénératives et même le cancer. Loin des discours simplistes, le Professeur Doré explique comment ce "partenaire invisible" influence notre santé mentale, notre réponse aux traitements contre le cancer, et notre vieillissement. Il partage les avancées révolutionnaires des transferts de microbiote fécal, une thérapie qui ouvre des perspectives fascinantes pour traiter de nombreuses pathologies. Il aborde également les vrais ennemis de notre microbiote - notamment les antibiotiques et l'alimentation ultra-transformée - et nous donne des clés concrètes pour le préserver. Le Professeur Doré démystifie le monde complexe des probiotiques, explique pourquoi le régime méditerranéen est une solution scientifiquement validée, et révèle comment le microbiote pourrait prédire notre réponse à l'immunothérapie contre le cancer. Il partage également sa vision du French Gut, un projet citoyen permettant à chacun de contribuer à la recherche tout en découvrant son propre microbiote. 💚 Une conversation aussi instructive qu'inspirante pour tous ceux qui souhaitent comprendre ce monde microbien invisible et optimiser leur santé globale à travers lui. 👉 Partagez cet épisode autour de vous. Pour en savoir plus sur le programme du French Gut 👉 https://lefrenchgut.fr/le-projet/comment-participer/ ------------------------------------------------------------------------------------------------------------------------------------------------------------------ 🔔 Abonnez-vous au podcast Healthier Humanity pour ne rater aucun épisode et vivre en meilleure santé, plus longtemps. ----------------------------------------------------------------------------------------------------------------------------------------------------------------- TIMELINE : 00:00 : Introduction : Rencontre avec le pionnier du microbiote 01:55 : L'organe oublié : 50 000 milliards de bactéries en nous 06:47 : Humain et microbien : nous sommes un écosystème 10:23 : Microbiote et maladies chroniques : les liens révélés 15:34 : Du microbiote au cerveau : l'axe intestin-cerveau 20:18 : Transfert de microbiote fécal : révolution thérapeutique 28:45 : Antibiotiques : l'ennemi invisible de votre microbiote 35:12 : Que faire après un traitement antibiotique ? 38:27 : Régime méditerranéen : la solution scientifiquement prouvée 45:33 : Probiotiques : démêler le vrai du faux 52:08 : Cancer et immunothérapie : quand le microbiote prédit la réponse 58:41 : French Gut : 100 000 microbiomes pour la science 64:15 : Tester son microbiote : pour qui et pourquoi ? 69:23 : Microbiote et vieillissement : les secrets de la longévité 74:50 : Conseils pratiques : nourrir son microbiote au quotidien 79:12 : Le mythe le plus répandu sur le microbiote 82:35 : Message de clôture : nous sommes symbiose * Le professeur Joël Doré n’entretient pas de liens d’intérêt avec la société productrice de ce podcast (Alan) et n’a pas été rémunéré pour répondre à cet entretien.

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