Natural medicine, Lions mane

Dr. John Campbell April 17, 2025
Video Thumbnail

About

No channel description available.

Video Description

Isle of Wight mushroom farm, https://www.iwmushrooms.co.uk/ Lions main, Hericium erinaceus Long history of usage in traditional Chinese medicine https://www.mdpi.com/2072-6643/17/8/1307 https://pubmed.ncbi.nlm.nih.gov/34169530/ Lots of bioactive compounds, polysaccharides (notably β-glucans), terpenoids, phenolic compounds, polyphenols, and peptides, bioactive proteins Diverse health-promoting properties. Functional food / mushroom, nutraceutical Safer and more sustainable health solutions Nutritional perspective Mushrooms, proteins, fibre, vitamins (B1, B2, B3, B5, B6 and D precursors), selenium, zinc, and potassium Low-calorie: high nutrient density ratio Prebiotic fibers, gut health, growth of beneficial microbiota, contributing to improved digestion and immune function Peripheral neuronal regeneration https://pubmed.ncbi.nlm.nih.gov/23510212/ Functional recovery following crush injury to the peroneal nerve in rats Stimulated regrowth of motor endplates/neuromuscular junction More rapid improvement in motor function PNS mechanisms Activation of genes in dorsal root ganglia neurons (cell bodies of sensory neurones) Activates genes to produce neurotrophins Neurotrophic factors, Nerve Growth Factor These promote cell survival and stimulate nerve fibre growth Promote protein synthesis in damaged neurones Central nervous system maintenance and regeneration Preventing and managing neurodegenerative diseases Preclinical studies, improvements in ischemic stroke, Parkinson's disease, Alzheimer's disease, Depression and anxiety Enhancing cognitive function https://restorativemedicine.org/wp-content/uploads/2017/12/lions-mane.pdf CNS mechanisms Can cross the blood brain barrier https://verybigbrain.com/nootropics/brain-cell-regeneration-the-remarkable-effects-of-lions-mane-mushroom/ Neurotrophic factors, Brain Derived Neurotrophic Factor, Nerve Growth Factor AD and PD, where oxidative stress plays a central role Scavenging reactive oxygen species and inducing endogenous antioxidant enzymes such as superoxide dismutase (SOD) Terpenoids Hericenones, A to L Fruiting body Stimulates NGR, and mimics NGF (mimetic) Cognitive enhancement and memory improvement Increases nerve cell growth, fibre formation, new connection formation in hippocampus Erinacenes, A to Z2 Mycelium Erinacine A, shown to increase nerve growth factor (NGF) levels in the brain, promoting neurogenesis and neuronal survival Stimulates NGF and is a brain anti-inflammatory Reducing neuroinflammation and systemic inflammation Suppressing glial cell inflammatory activation (Excessive microglial activation is a known problem in AD, oxidative stress accelerates neuronal damage) Potent neuroprotective effects Anti-inflammatory, antioxidant, immunological effects Chronic inflammation and oxidative stress are underlying factors in a wide range of diseases, Including cardiovascular disorders, diabetes, neurodegenerative illnesses, and cancer Conventional treatments rely on synthetic drugs,  significant side effects and long-term health risks Neutralize ROS and reduce oxidative stress in neuronal cells Downregulate pro-inflammatory cytokines (IL-6, TNF-α, IL-1β), while upregulating anti-inflammatory cytokines. Reduced prostaglandin synthesis (COX 2 inhibitor) Immunomodulatory Restoring gut microbiota, reducing systemic inflammation Extract significantly increased SOD, CAT, and GPx levels, protecting liver cells from oxidative damage Antimicrobial activities Antibiotic effect Inhibiting bacterial protein synthesis Bacteriostatic Bactericidal Rise in antibiotic-resistant pathogens, overuse, disuse, MRSA, MDRTB - significant threat to public health Several studies suggest that its bioactive compounds may act synergistically with conventional antibiotics, improving antimicrobial activity All extracts displayed antibacterial activity against both Gram-positive and Gram-negative bacteria, novel mechanisms of action, Potential applications in combating antibiotic-resistant infections. Active against MRSA Antibiotic mechanisms Prevents biofilm formation Phenolic compounds, have been shown to interfere with bacterial and fungal cell membranes Gram-positive bacteria, which have a thick peptidoglycan layer that is more susceptible to membrane-targeting agents Inhibit key bacterial enzymes involved in cell wall synthesis, DNA replication, and energy metabolism Safety of lions mane use Generally recognized as safe (GRAS) Allergies Anticoagulants, antiplatelet Idiosyncratic interactions possible but unlikely

Upgrade Your Everyday

AI-recommended products based on this video

Loading...
Kasa Smart Outdoor Smart Plug by TP-Link (KP400) - Smart WiFi Outlet with 2 Sockets, IP64 Waterproof, Works with Alexa and Google Home, 2.4GHz WiFi Required, No Hub Required, Sunset & Sunrise Offset

Kasa Smart Outdoor Smart Plug by TP-Link (KP400) - Smart WiFi Outlet with 2 Sockets, IP64 Waterproof, Works with Alexa and Google Home, 2.4GHz WiFi Required, No Hub Required, Sunset & Sunrise Offset

(28,846)
$21.99$17.99
FREE delivery Wed, Aug 20 on your first order
1K+ bought in past month
Loading...
Monster Wireless Earbuds Open Ear AC311, Bluetooth 5.4 Open Ear Headphones, Up to 30 Hours Playtimes Bluetooth Ear Earphones with Stereo Sound, Touch Control and IPX5 Waterproof Open Ear Buds

Monster Wireless Earbuds Open Ear AC311, Bluetooth 5.4 Open Ear Headphones, Up to 30 Hours Playtimes Bluetooth Ear Earphones with Stereo Sound, Touch Control and IPX5 Waterproof Open Ear Buds

(1)
$89.99
FREE delivery Wed, Apr 1
Loading...
Wireless Earbuds, Sports Bluetooth Headphones, 80Hrs Playtime Ear Buds with LED Power Display, Noise Canceling Headset, IPX7 Waterproof Earphones for Workout/Running Z(Black)

Wireless Earbuds, Sports Bluetooth Headphones, 80Hrs Playtime Ear Buds with LED Power Display, Noise Canceling Headset, IPX7 Waterproof Earphones for Workout/Running Z(Black)

(329)
$39.99
Prime
100+ bought in past month
Loading...
Monster Wireless Earbuds, Bluetooth 5.4 in Ear Stereo Headphones, Built-in Mic for Crystal Clear Call, 32H Playtime, Comfortable Fit, Fast Charging, Waterproof Earphones for Sports, Black

Monster Wireless Earbuds, Bluetooth 5.4 in Ear Stereo Headphones, Built-in Mic for Crystal Clear Call, 32H Playtime, Comfortable Fit, Fast Charging, Waterproof Earphones for Sports, Black

(47)
$119.59
FREE delivery Mon, Mar 9
Loading...
Wireless Earbuds, Sports Bluetooth Headphones, 80Hrs Playtime Ear Buds with LED Power Display, Noise Canceling Headset, IPX7 Waterproof Earphones for Workout/Running Z(Black)

Wireless Earbuds, Sports Bluetooth Headphones, 80Hrs Playtime Ear Buds with LED Power Display, Noise Canceling Headset, IPX7 Waterproof Earphones for Workout/Running Z(Black)

(346)
$39.99
Prime
2K+ bought in past month
Loading...
Brita Stainless Steel Premium Filtering Water Bottle, BPA-Free, Reusable, Insulated, Replaces 300 Plastic Water Bottles, Filter Lasts 2 Months or 40 Gallons, Includes 1 Filter, Carbon - 20 oz.

Brita Stainless Steel Premium Filtering Water Bottle, BPA-Free, Reusable, Insulated, Replaces 300 Plastic Water Bottles, Filter Lasts 2 Months or 40 Gallons, Includes 1 Filter, Carbon - 20 oz.

(2,652)
$81.37$76.36
FREE delivery Sep 29 - Oct 2
Loading...
Simple Modern Filtered Water Bottle | Insulated Stainless-Steel Carbon Filter Travel Water Bottles | Reusable for Clean Drinking Water On The Go | 24oz, Sea Glass Sage

Simple Modern Filtered Water Bottle | Insulated Stainless-Steel Carbon Filter Travel Water Bottles | Reusable for Clean Drinking Water On The Go | 24oz, Sea Glass Sage

(26)
$30.13
FREE delivery Tue, Sep 23 on your first order
Loading...
FITVII Health & Fitness Tracker (Answer/Make Calls), Smart Watch with 24/7 Heart Rate and Blood Pressure, Sleep Tracking Monitor, 120+ Sport Mode Activity Tracker

FITVII Health & Fitness Tracker (Answer/Make Calls), Smart Watch with 24/7 Heart Rate and Blood Pressure, Sleep Tracking Monitor, 120+ Sport Mode Activity Tracker

(198)
$59.99
FREE delivery Sun, Aug 10
100+ bought in past month
Loading...
AYATAHA AYATAHA Smart Watch for Kids, Smartwatch Fitness Tracker for Boys Girls, Children's Activity Watch 37 Sports Modes SMS Notification, HD Full Touchscreen IP67 Waterproof, Blue

AYATAHA AYATAHA Smart Watch for Kids, Smartwatch Fitness Tracker for Boys Girls, Children's Activity Watch 37 Sports Modes SMS Notification, HD Full Touchscreen IP67 Waterproof, Blue

(55)
$41.99
PrimeFREE delivery Sat, Jun 14
Loading...
Iaret Iaret Smart Watch for Women, 1.83" HD Fitness Tracker with 4 Bands, Answer/Make Calls, Heart Rate/Sleep/SpO2/Step Tracking, 100+ Sport Modes, Android/iPhone Compatible Gift (Rose Gold)

Iaret Iaret Smart Watch for Women, 1.83" HD Fitness Tracker with 4 Bands, Answer/Make Calls, Heart Rate/Sleep/SpO2/Step Tracking, 100+ Sport Modes, Android/iPhone Compatible Gift (Rose Gold)

(42)
$59.99
FREE delivery Thu, Jun 19
100+ bought in past month
Loading...
Smart Watch for Men Women 1.8" Fitness Tracker, Bluetooth Call, DIY Dial, Heart Rate Sleep Blood Oxygen Monitor, 100+ Sports Modes, IP68 Waterproof Smartwatch for Android iPhone, Alexa Built-in

Smart Watch for Men Women 1.8" Fitness Tracker, Bluetooth Call, DIY Dial, Heart Rate Sleep Blood Oxygen Monitor, 100+ Sports Modes, IP68 Waterproof Smartwatch for Android iPhone, Alexa Built-in

(980)
$39.99
FREE delivery Sun, Sep 21
300+ bought in past month
Loading...
Hand Warmers 2 Pack, 14000mAh Rechargeable Hand Warmers, Electric Hand Warmer Reusable, Portable Power Bank USB Hand Warmers 4 Levels 8 Heating, Gifts for Raynauds Ski Golf Camping

Hand Warmers 2 Pack, 14000mAh Rechargeable Hand Warmers, Electric Hand Warmer Reusable, Portable Power Bank USB Hand Warmers 4 Levels 8 Heating, Gifts for Raynauds Ski Golf Camping

(683)
$74.08$59.47
FREE delivery Jun 13 - 18
Loading...
Hand Warmers Rechargeable, 10000mAh Electric Heated Gloves Power Bank Portable Graphene Handwarmers Pouch with 3 Levels & Double-Sided Heating for Hunting Camping Golf Xmas Gifts for Women Men Kids

Hand Warmers Rechargeable, 10000mAh Electric Heated Gloves Power Bank Portable Graphene Handwarmers Pouch with 3 Levels & Double-Sided Heating for Hunting Camping Golf Xmas Gifts for Women Men Kids

(651)
$44.99
PrimeFREE delivery Sun, Jun 15
Loading...
2Pack Rechargeable Hand Warmer, 8000mAh Electric Hand Warmer Power Bank, Portable USB-C Hand Warmer for Pocket, Reusable Hand Warmer Up to 8 hrs Each, Warm Gift for Men Women, for Hunting, Camping
Amazon's Choice

2Pack Rechargeable Hand Warmer, 8000mAh Electric Hand Warmer Power Bank, Portable USB-C Hand Warmer for Pocket, Reusable Hand Warmer Up to 8 hrs Each, Warm Gift for Men Women, for Hunting, Camping

(1,128)
$15.99
FREE delivery Sat, Jun 14 on your first order
Loading...
GTOCE Portable Charger,40000mAh Power Bank with 22.5W Fast Charging LED Digital Display Battery Pack with 6 Outputs 2 Inputs, Type C Powerbank Portable Charger for iPhone 16 pro Samsung AirPods,Black

GTOCE Portable Charger,40000mAh Power Bank with 22.5W Fast Charging LED Digital Display Battery Pack with 6 Outputs 2 Inputs, Type C Powerbank Portable Charger for iPhone 16 pro Samsung AirPods,Black

(334)
$42.99
FREE delivery Thu, Oct 16
1K+ bought in past month
Loading...
Monster Sleep Ear200, Wireless in-Ear Headphones, Bluetooth 6.0 Sleep Headphones, with ANC Active Noise Cancellation Designed for Side Sleepers, 30 Hours of bass Stereo Sound.

Monster Sleep Ear200, Wireless in-Ear Headphones, Bluetooth 6.0 Sleep Headphones, with ANC Active Noise Cancellation Designed for Side Sleepers, 30 Hours of bass Stereo Sound.

(10)
$39.99
FREE delivery Tue, Mar 24
Loading...
Monster Sleep Ear100 Ear Buds, Sleep Earbuds with Stereo Sound, Design for Side Sleeper, 32H Playtime, Bluetooth 6.0, ENC Noise Cancelling, IPX6 Waterproof Mini Headphones, White

Monster Sleep Ear100 Ear Buds, Sleep Earbuds with Stereo Sound, Design for Side Sleeper, 32H Playtime, Bluetooth 6.0, ENC Noise Cancelling, IPX6 Waterproof Mini Headphones, White

(4)
$39.99
FREE delivery Mon, Mar 2
Loading...
Monster Sleep Ear100 Ear Buds, Sleep Earbuds with Stereo Sound, Design for Side Sleeper, 32H Playtime, Bluetooth 6.0, ENC Noise Cancelling, IPX6 Waterproof Mini Headphones, Black

Monster Sleep Ear100 Ear Buds, Sleep Earbuds with Stereo Sound, Design for Side Sleeper, 32H Playtime, Bluetooth 6.0, ENC Noise Cancelling, IPX6 Waterproof Mini Headphones, Black

(15)
$39.99
FREE delivery Mon, Feb 23
Loading...
Monster Sleep Ear100 Ear Buds, Sleep Earbuds with Stereo Sound, Design for Side Sleeper, 32H Playtime, Bluetooth 6.0, ENC Noise Cancelling, IPX6 Waterproof Mini Headphones, Black

Monster Sleep Ear100 Ear Buds, Sleep Earbuds with Stereo Sound, Design for Side Sleeper, 32H Playtime, Bluetooth 6.0, ENC Noise Cancelling, IPX6 Waterproof Mini Headphones, Black

(6)
$39.99
FREE delivery Sat, Dec 27
Loading...
Hydroponics Growing System Indoor Garden - Herb Garden with Grow Light, 15 Pods Stainless Steel Indoor Garden Kit, Auto Timer, Gardening Gift for All Ages

Hydroponics Growing System Indoor Garden - Herb Garden with Grow Light, 15 Pods Stainless Steel Indoor Garden Kit, Auto Timer, Gardening Gift for All Ages

(24)
$206.57$200.61
FREE delivery Jun 13 - 17
Loading...
Umbra Triflora Hanging Planter for Window, Indoor Herb Garden, Set of 5, White/Black

Umbra Triflora Hanging Planter for Window, Indoor Herb Garden, Set of 5, White/Black

(7,808)
$71.52
PrimeFREE delivery Sat, Jun 14
Loading...
Large Hydroponics Growing System 14 Pods, Indoor Herb Garden with LED Grow Light, 5L Water Tank, Hydroponic Grow Kit with 3 Auto-Timers, Rotatable Light Panel and Child Lock for Home School Gardening

Large Hydroponics Growing System 14 Pods, Indoor Herb Garden with LED Grow Light, 5L Water Tank, Hydroponic Grow Kit with 3 Auto-Timers, Rotatable Light Panel and Child Lock for Home School Gardening

(119)
$167.81
FREE delivery Jun 16 - 20
Loading...
Hanging Planter Hanging Plant Holder, 6 Inch 4 Indoor Plant Pots, Wall/Window Plant Hanger Indoor Herb Garden

Hanging Planter Hanging Plant Holder, 6 Inch 4 Indoor Plant Pots, Wall/Window Plant Hanger Indoor Herb Garden

(269)
$35.99$28.90
PrimeFREE delivery Sat, Jun 14
Loading...
slopehill Multi Hair Stylers & Hair Straightener - 2 in 1 Wet to Dry Air Straightener and Hair Dryer Combo with High Speed Air + Rapid Heat-Up + Customizable Temperature(Pink)

slopehill Multi Hair Stylers & Hair Straightener - 2 in 1 Wet to Dry Air Straightener and Hair Dryer Combo with High Speed Air + Rapid Heat-Up + Customizable Temperature(Pink)

(177)
$139.99
Prime
Loading...
Hi.FANCY Portable Laptop Stand with Dual Cooling Fans for 14-17inch Laptops, Grey, 23.5 x 25.9 x 0.95cm

Hi.FANCY Portable Laptop Stand with Dual Cooling Fans for 14-17inch Laptops, Grey, 23.5 x 25.9 x 0.95cm

(0)
$36.99
FREE delivery Aug 18 - 28
Loading...
Laptop Stand for Desk, Adjustable Laptop Riser ABS+Silicone Foldable Portable Laptop Holder, Ventilated Cooling Notebook Stand for 10-15.6” Laptops,Tablet-Black

Laptop Stand for Desk, Adjustable Laptop Riser ABS+Silicone Foldable Portable Laptop Holder, Ventilated Cooling Notebook Stand for 10-15.6” Laptops,Tablet-Black

(11,679)
$14.99
FREE delivery Sat, Jun 14 on your first order
500+ bought in past month
Loading...
JETech 5 in 1 Case for Samsung Galaxy S25 Ultra 5G with 2-Pack Each Tempered Glass Screen Protector and Camera Lens Protector, Non-Yellowing Shockproof Bumper Phone Cover (Clear)

JETech 5 in 1 Case for Samsung Galaxy S25 Ultra 5G with 2-Pack Each Tempered Glass Screen Protector and Camera Lens Protector, Non-Yellowing Shockproof Bumper Phone Cover (Clear)

(197)
$15.99
FREE delivery Sat, Jun 14 on your first order
100+ bought in past month
Loading...
TAURI for iPhone 17 Pro Max Case 6.9" with 1-Pack Screen Protector, Camera Lens Full Protection, Military-Grade Protection, Shockproof Transparent Back Bumper Phone Cover - Clear Global Recycled Standard

TAURI for iPhone 17 Pro Max Case 6.9" with 1-Pack Screen Protector, Camera Lens Full Protection, Military-Grade Protection, Shockproof Transparent Back Bumper Phone Cover - Clear Global Recycled Standard

(0)
$10.76
FREE delivery Thu, Oct 16 on your first order
2K+ bought in past month
Loading...
TAURI for iPhone 17 Pro Case 6.3" with 1-Pack Screen Protector, Camera Lens Full Protection, Military-Grade Protection, Shockproof Transparent Back Bumper Phone Cover - Clear Global Recycled Standard
Best Seller

TAURI for iPhone 17 Pro Case 6.3" with 1-Pack Screen Protector, Camera Lens Full Protection, Military-Grade Protection, Shockproof Transparent Back Bumper Phone Cover - Clear Global Recycled Standard

(61,696)
$10.76
Prime
2K+ bought in past month
Loading...
JOINPAYA 1Set Rechargeable Hand Warmer Hand Heater for Winter Heating Levels Compact

JOINPAYA 1Set Rechargeable Hand Warmer Hand Heater for Winter Heating Levels Compact

(0)
$9.29
FREE delivery Jun 20 - Jul 4
Loading...
Shakven Rechargeable Hand Warmer | Cute Comfortable Portable Hand Warmers,Ergonomic Adjustable Energy-Efficient Small Heater for Travel, Outdoor, Winter

Shakven Rechargeable Hand Warmer | Cute Comfortable Portable Hand Warmers,Ergonomic Adjustable Energy-Efficient Small Heater for Travel, Outdoor, Winter

(0)
$26.93
FREE delivery Jun 19 - Jul 2
Loading...
OCOOPA IP45 Waterproof Hand Warmer Rechargeable, Up to 15hrs Heat,10000mAh Durable Quick Charge Electric Hand Heater, PD Compatible, 3 Levels for Outdoors, Heavy Duty, H01-PD PRO

OCOOPA IP45 Waterproof Hand Warmer Rechargeable, Up to 15hrs Heat,10000mAh Durable Quick Charge Electric Hand Heater, PD Compatible, 3 Levels for Outdoors, Heavy Duty, H01-PD PRO

(50)
$39.99
PrimeFREE delivery Sat, Jun 14
Loading...
OCOOPA IP45 Waterproof Hand Warmer Rechargeable, Up to 15hrs Heat,10000mAh Durable Quick Charge Electric Hand Heater, PD Compatible, 3 Levels for Outdoors, Heavy Duty, H01-PD PRO

OCOOPA IP45 Waterproof Hand Warmer Rechargeable, Up to 15hrs Heat,10000mAh Durable Quick Charge Electric Hand Heater, PD Compatible, 3 Levels for Outdoors, Heavy Duty, H01-PD PRO

(649)
$39.99
PrimeFREE delivery Sat, Jun 14