This Study Single Handedly Changed the Way I Think about Fiber
Nick Norwitz
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MD, Harvard & PhD, Oxford & | My Motto is "Stay Curious" | Enthusiastic About All Matters Metabolic Health | Thanks for Learning with Me! Please also follow at my Newsletter at "StayCuriousMetabolism.com" where you can find more deep dives into metabolism that will be worth your time and upgrade your health. Disclaimer: While I am an MD PhD, this channel is intended to educate. It is not intended to provide clinical recommendations for any individual. Please contact your doctor or other clinical provider if you have questions about your care.
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For the references & a written breakdown, see this StayCurious Newsletter. This is also where you can always get extra insights and early access to breakdowns: https://staycuriousmetabolism.substack.com/p/the-fiber-that-fights-fat-how-inulin?r=40ekz2 What if a simple fiber could protect you from the metabolic chaos caused by sugar? In this video, we explore new 2025 research showing how inulin, a specific prebiotic fiber found in foods like chicory root, garlic, and artichokes, can effectively “immunize” your metabolism against fructose. Instead of letting sugar turn into fat in your liver, inulin helps your body redirect fructose into amino acid and antioxidant pathways, reducing fatty liver, insulin resistance, and inflammation in the process. This isn’t “fiber fluff.” This is exciting and emerging science that reshapes how we think about fiber, sugar metabolism, and long-term health. Chapters 0:00 – This Paper Changed How I See Fiber & Metabolism 1:26 – Fatty Liver & Metabolic Dysfunction Risk 2:53 – Can You Immunize Against Fructose? 3:42 – Fructose vs Inulin Study Design 4:09 – Inulin Improves Body Composition & Insulin Sensitivity 5:25 – Inulin Reduces Fatty Liver & Inflammation 5:56 – Inulin Rewires Liver Metabolism 6:50 – Fructose Metabolism Explained 7:40 – Inulin Boosts Fructose Catabolism & Lowers Spillover 9:01 – Inulin Turns Sugar Into Protein & Glutathione 11:06 – Inulin-Rich Foods for Gut Health 12:13 – What I’m Doing — Applying the Science 13:03 – Not All Fiber Is Equal: Why Inulin Stands Out #fiber #metabolichealth #metabolism #obesity #diabetes #glutathione #inulin #insulinresistance #metabolicdysfunction #mitochondrial #fructose #protein #educational #fattyliver #prebiotic #guthealth #microbiome #shortchainfattyacids #SCFA #nutritionalscience #digestivehealth #glucosemetabolism #liverhealth #fatburning #healthoptimization #functionalfood #longevityscience #sciencecommunication #nutritionscience #staycurious
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