The Science of Metabolic Health: Mitochondria, Zone 2, Diet, Fat Storage | The Proof Podcast EP #329

Video Description

Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists in Episode #329. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease. 👇 Visit The Proof website for the full show notes and supporting studies. 👇 https://theproof.com/podcast/ In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD. Specifically, we discuss: 00:00 - Intro 01:35 - What is Metabolic Health 07:02 - Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility 20:03 - The Importance of Skeletal Muscle for Metabolic Health 28:36 - Exercise for Metabolic Health - Zone 2 56:45 - Twin Cycle Hypothesis 01:08:15 - Understanding the Personal Fat Threshold 01:17:08 - Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor 01:36:46 - Are DASH, Nordic, Mediterranean, and Portfolio Diets Good for Preventing and Managing Diabetes? 01:42:39 - Understanding Non-Alcoholic Fatty Liver Disease and Its Development 01:49:37 - The Science of Hepatic Fat Oxidation 01:55:14 - Consequences and Effects of Fatty Liver Disease 02:00:42 - Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes 02:13:21 - Combination of Fructose and Saturated Fat on Metabolic Health 02:17:35 - Type of Fat and Its Effect on Metabolic Health 02:24:01 - What Causes Metabolic Health: Fat or Fructose 02:27:50 - New Fat Storage Mechanisms - Personal Fat Threshold 02:31:52 - Modern Techniques for Accurate Body Fat Measurement 02:36:51 - Health Metabolic Biomarkers 02:38:19 - Ectopic Fat 02:39:10 - Fat Storage and Metabolic Health 02:42:02 - Evolutionary Insights into Human Fat Storage 02:45:46 - Fatty Liver Disease 02:57:46 - Outro Connect with featured guests: - Inigo San Millan, PhD: https://theproof.com/tag/inigo-san-millan/ - Don Layman, PhD: https://theproof.com/tag/don-layman/ - Roy Taylor, PhD: https://theproof.com/tag/roy-taylor/ - Andrea Glenn, PhD, RD: https://theproof.com/tag/andrea-glenn/ - Alan Flanagan, PhD: https://theproof.com/tag/alan-flanagan/ - Richard Johnson, MD: https://theproof.com/tag/richard-johnson/ - Christos Mantzoros MD, DSc, PhD: https://theproof.com/tag/christos-mantzoros/ The best way to support the show is to use the products and services offered by our sponsors. To check them out and enjoy great savings, visit theproof.com/friends. Enjoy, friends. Simon This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Head to https://38tera.com https://38tera.com/ and use code THEPROOF for a discount at checkout. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon http://drinklmnt.com/simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends http://theproof.com/friends You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com http://theproof.com/ and host of The Proof with Simon Hill https://theproof.com/podcast/ Author of The Proof is in the Plants https://theproof.com/book/ Watch the episodes on YouTube https://www.youtube.com/c/TheProofWithSimonHill?sub_confirmation=1 or listen on Apple https://podcasts.apple.com/au/podcast/the-proof-with-simon-hill/id1367773989 / Spotify https://open.spotify.com/show/7bAIJCVgnquxXZuQCdZyTi?si=84831dc34dc9408b Connect with me on Instagram https://www.instagram.com/theproof/ , Twitter https://mobile.twitter.com/theproof, and Facebook https://facebook.com/theproofwithsimonhill Nourish your gut with my Plant-Based Ferments Guide https://theproof.com/ferments/ Download my complimentary Two-Week Meal Plan https://plantproof.com/mealplan and high protein Plant Performance recipe book https://theproof.com/performance/